Annual Scientific Report 2015

Abstract

The major goal in the Martin group is to provide solutions to relevant and challenging synthetic problems from the scientific and industrial standpoint, without losing sight its environmental impact. In order to meet these challenges, the group is mainly focused on the metal-catalyzed, selective activation of relatively inert entities of great significance, such as CO₂, C-H bonds, C-C bonds and C-O bonds, as these motifs rank amongst the most widespread and fundamental linkages in organic chemistry. We are also interesting on the design and implementation of metal-catalyzed domino reactions since a high degree of molecular complexity can be achieved in a one-step, hence allowing a rapid access to key backbones occurring in many natural products.

Topics addressed

• Ni-catalyzed reductive cleavage of C-O Bonds
• Metal-catalyzed C-H bond-functionalization
• Ni-catalyzed CO₂ Activation

Articles

“Ni-Catalyzed Borylation of Aryl Fluorides via C-F Cleavage“
J. Am. Chem. Soc. (2015), 137, 12470-12473
X.-W. Liu, J. Echavarren, C. Zarate, R. Martin

“Ni-Catalyzed Regioselective Hydrocarboxylation of Alkynes with CO2 by Using Simple Alcohols as Proton Sources”
J. Am. Chem. Soc. (2015), 137, 8924-8927
X. Wang, M. Nakajima, R. Martin

“Ipso-Borylation of Aryl Ethers via Ni-catalyzed C-OMe Cleavage”
J. Am. Chem. Soc. (2015), 137, 6754-6757
C. Zárate, R. Manzano, R. Martin

“Nickel-Catalyzed Chemo-, Regio- and Diastereoselective Bond-Formation through Proximal C-C Cleavage of Benzocyclobutenones”
Angew. Chem. Int. Ed. (2015), 54, 9537-9541
F. Julià-Hernández, A. Ziadi, A. Nishimura, R. Martin

“Ni-Catalyzed Divergent Cyclization/Carboxylation of Unactivated Primary and Secondary Alkyl Halides with CO₂”
J. Am. Chem. Soc. (2015), 137, 6476-6479
X. Wang, Y. Liu, R. Martin

“Nickel-Catalyzed Enantioselective C-C Bond Formation through C(sp2)-O Cleavage in Aryl Esters”
J. Cornella, E. P. Jackson, R. Martin
Angew. Chem. Int. Ed. (2015), 54, 4075-4078